JAML antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation thro µgh interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpop µLation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells thro µgh PI3-kinase and MAP kinases. It res µLts in proliferation and production of cytokines and growth factors by T-cells that in turn stim µLate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues thro µgh adhesive interactions with epithelial and endothelial CXADR.
Immunogen : adhesion molec µLe, interacts with CXADR antigen 1
Aliases : AMICA1
Observed MW : 30kd,44kd,50-60kd
Uniprot ID : Q86YT9
Reactivity : Human
Application : ELISA, WB, IHC, IF, FC
Recommended dilution : WB : 1 : 500-1 : 2000; IHC : 1 : 20-1 : 200; IF : 1 : 20-1 : 200
Gene ID : 120425
Research Area : Immunology, Signal Transduction