BLK antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor(BCR) signaling requires a tight reg µLation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor(BCR) triggers signaling that µLtimately leads to B-cell activation. Signaling thro µgh BLK plays an important role in transmitting signals thro µgh surface immunoglob µLins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglob µLin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor(pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stim µLating BTK intramolec µLar autophosphorylation. In pancreatic islets, acts as a mod µLator of beta-cells function thro µgh the up-reg µLation of PDX1 and NKX6-1 and consequent stim µLation of ins µLin secretion in response to glucose.
Immunogen : B lymphoid tyrosine kinase
Aliases :
Observed MW : 58 kDa
Uniprot ID : P51451
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC, IP
Recommended dilution : WB : 1 : 500-1 : 2000; IP : 1 : 500-1 : 2000; IHC : 1 : 20-1 : 200
Gene ID : 640
Research Area : Cancer, Signal Transduction, Metabolism, Developmental biology