BHLHE41 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Transcriptional repressor involved in the reg µLation of the circadian rhythm by negatively reg µLating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoreg µLatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator : CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively reg µLates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
Immunogen : basic helix-loop-helix family, member e41
Aliases : BHLHB3, DEC2, SHARP1
Observed MW : 51 kDa, 75 kDa
Uniprot ID : Q9C0J9
Reactivity : Human, Mouse, Rat
Application : ELISA, WB
Recommended dilution : WB : 1 : 1000-1 : 2000
Gene ID : 79365
Research Area : Neuroscience, Epigenetics, Metabolism, Developmental biology