Bestrophin 1 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background : This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may reg µLate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform mac µLar dystrophy (VMD2), also known as Best mac µLar dystrophy, in addition to ad µLt-onset vitelliform mac µLar dystrophy (AVMD) and other retinopathies. Alternative splicing res µLts in m µLtiple variants encoding distinct isoforms.
Immunogen : bestrophin 1
Aliases : BEST
Observed MW : 70 kDa
Uniprot ID : O76090
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC
Recommended dilution : WB : 1 : 500 - 1 : 2000; IHC : 1 : 50 - 1 : 200
Gene ID : 7439
Research Area : Neuroscience