Angiotensinogen antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Angiotensinogen is a precursor of angiotensin II(Ang II), is expressed and syntheVolumed largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vasc µLar constriction and reg µLating salt and fluid homeostasis. The res µLting product, angiotensin I, is then cleaved by angiotensin converting enzyme(ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tub µLar dysgenesis, a severe disorder of renal tub µLar development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Immunogen : angiotensinogen(serpin peptidase inhibitor, clade A, member 8)
Aliases : AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, FLJ92595, FLJ97926, Serpin A8, SERPINA8
Observed MW : 53 kDa
Uniprot ID : P01019
Reactivity : Human, Mouse
Application : ELISA, WB, IHC, FC
Recommended dilution : WB : 1 : 200-1 : 2000; IHC : 1 : 20-1 : 200
Gene ID : 183
Research Area : Cardiovasc µLar, Metabolism