BTRC Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Beta transducin repeat containing E3 ubiquitin protein ligase antibody; beta TrCP1 antibody; beta-transducin repeat containing antibody; BETA-TRCP antibody; betaTrCP antibody; btrC antibody; bTrCP antibody; bTrCP1 antibody; E3RSIkappaB antibody; F box and WD repeat protein 1B antibody; F box and WD repeats protein beta TrCP antibody; F-box and WD repeats protein beta-TrCP antibody; F-box/WD repeat protein 1A antibody; F-box/WD repeat-containing protein 1A antibody; FBW1A antibody; FBW1A_HUMAN antibody; FBXW1 antibody; FBXW1A antibody; FWD1 antibody; HOS antibody; mKIAA4123 antibody; pIkappaBalpha-E3 receptor subunit antibody; Slimb antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y297
Immunogen : Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Substrate recognition component of a SCF (SKP1-C µL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at \'Lys-21\' and \'Lys-22\'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed : 25704143, PubMed : 25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1 FBXO5, PER1 SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation thro µgh a DBB1-C µL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1 IKBKB and TNF. Required for proteolytic processing of GLI3.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BTRC
Research Areas : Neuroscience; Cell biology; Microbiology