BHLHE41 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : Basic helix-loop-helix domain containing class B3 antibody; BHE41_HUMAN antibody; bHLH protein DEC2 antibody; bHLHB3 antibody; bHLHe41 antibody; Class B basic helix loop helix protein 3 antibody; Class B basic helix-loop-helix protein 3 antibody; Class E basic helix-loop-helix protein 41 antibody; DEC2 antibody; Differentially expressed in chondrocytes protein 2 antibody; Enhancer of split and hairy related protein 1 antibody; Enhancer-of-split and hairy-related protein 1 antibody; hDEC2 antibody; Moderately similar to basic-helix loop helix protein M.musc µLus antibody; SHARP-1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9C0J9
Immunogen : Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcriptional repressor involved in the reg µLation of the circadian rhythm by negatively reg µLating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoreg µLatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator : CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5\'-CACGTG-3\') found within the promoters of its target genes. Negatively reg µLates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BHLHE41
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction