FZD8 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : Frizzled 8 seven transmembrane spanning receptor antibody; frizzled 8, seven transmembrane spanning receptor antibody; Frizzled family receptor 8 antibody; frizzled homolog 8 (Drosophila) antibody; Frizzled homolog 8 antibody; Frizzled-8 antibody; FZ 8 antibody; Fz-8 antibody; FZ8 antibody; FZD 8 antibody; FZD8 antibody; FZD8_HUMAN antibody; hFZ 8 antibody; hFz8 antibody; HGNC4046 antibody; Homolog of Drosophila Frizzled 8 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H461
Immunogen : Recombinant Human Frizzled-8 protein (55-233AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling thro µgh inducing aggregation of receptor-ligand complexes into ribosome-Volumed signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accum µLation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercell µLar transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FZD8
Research Areas : Others