JARID2 Antibody Biotin conjugated
Volume : 50 µg
Clone Number :
Aliases : JARD2 antibody; JARD2_HUMAN antibody; JARID2 antibody; JMJ antibody; Jumonji AT rich interactive domain 2 antibody; Jumonji homolog antibody; Jumonji like protein antibody; Jumonji protein antibody; Jumonji/ARID domain containing protein 2 antibody; Jumonji/ARID domain-containing protein 2 antibody; Protein Jumonji antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q92833
Immunogen : Recombinant Human Protein Jumonji protein (1-159AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Reg µLator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by mod µLating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but reg µLates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of \\\'Lys-27\\\' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of \\\'Lys-9\\\' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative reg µLation of cell proliferation signaling.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : JARID2
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience