BICD2 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : bA526D8.1 antibody; Bic D 2 antibody; Bic-D 2 antibody; Bicaudal D homolog 2 (Drosophila) antibody; Bicaudal D homolog 2 antibody; Bicd2 antibody; BICD2_HUMAN antibody; Coiled coil protein BICD2 antibody; Cytoskeleton like bicaudal D protein homolog 2 antibody; Homolog of Drosophila bicaudal D antibody; KIAA0699 antibody; Protein bicaudal D homolog 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8TD16
Immunogen : Recombinant Human Protein bicaudal D homolog 2 protein (511-625AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtub µLe for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Reg µLates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic retic µLum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed : 25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry thro µgh reg µLation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BICD2
Research Areas : Signal transduction