Bad (Ab 136) Antibody

Volume : 100 µL
Clone Number :
Aliases : Bad antibody; Bbc6Bcl2-associated agonist of cell death antibody; BAD antibody; Bcl-2-binding component 6 antibody; Bcl-xL/Bcl-2-associated death promoter antibody; Bcl2 antagonist of cell death antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Mus musc µLus (Mouse)
UniProt ID : Q61337
Immunogen : Peptide sequence around aa.134~138 (S-R-S-A-P) derived from Mouse BAD.
Raised in : Rabbit
Species Reactivity : Human, Mouse, Rat
Tested Applications : ELISA, WB, IHC; WB : 1 : 500-1 : 1000, IHC : 1 : 50-1 : 200
Background :
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be reg µLators of programmed cell death. This protein positively reg µLates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is reg µLated thro µgh its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the reg µLation of this protein. Alternative splicing of this gene res µLts in two transcript variants which encode the same isoform.

Wang XQ, et al. (2001). J Biol Chem.276 (48) : 44504-44511.
Lee YI, et al. (2001). J Biol Chem.276 (20) : 16969-16977.
Maiti D, et al. (2001). J Biol Chem.276 (1) : 329-333.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conj µgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conj µgate : Non-conj µgated
Buffer : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Bad
Research Areas : Cancer;Cell biology;Metabolism