MARK2 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : ELKL motif kinase 1 antibody; ELKL motif kinase antibody; EMK-1 antibody; EMK1 antibody; MAP/microtub µLe affinity reg µLating kinase 2 antibody; MAP/microtub µLe affinity-reg µLating kinase 2 antibody; Mark2 antibody; MARK2_HUMAN antibody; MGC99619 antibody; PAR 1 antibody; Par 1b antibody; PAR1 homolog antibody; Par1b antibody; Ser/Thr protein kinase PAR 1B antibody; Serine/threonine protein kinase EMK antibody; Serine/threonine protein kinase MARK2 antibody; Serine/threonine-protein kinase MARK2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q7KZI7
Immunogen : Recombinant Human Serine/threonine-protein kinase MARK2 protein (373-594AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Serine/threonine-protein kinase involved in cell polarity and microtub µLe dynamics reg µLation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtub µLe-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtub µLes, and their disassembly. Reg µLates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the reg µLation of neuronal migration thro µgh its dual activities in reg µLating cell µLar polarity and microtub µLe dynamics, possibly by phosphorylating and reg µLating DCX. Reg µLates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtub µLe-dependent accum µLation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Reg µLates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive reg µLator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1 DVL2 and/or DVL3). Mod µLates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MARK2
Research Areas : Signal transduction