BIRC3 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : AIP 1 antibody; AIP1 antibody; API 2 antibody; API2 antibody; Apoptosis inhibitor 2 antibody; Bac µLoviral IAP repeat containing 3 antibody; Bac µLoviral IAP repeat containing protein 3 antibody; Bac µLoviral IAP repeat-containing protein 3 antibody; BIRC 3 antibody; BIRC3 antibody; BIRC3_HUMAN antibody; C IAP2 antibody; C-IAP2 antibody; Cell µLar inhibitor of apoptosis 2 antibody; cell µLar inhibitor of apoptosis protein 2 antibody; CIAP 2 antibody; CIAP2 antibody; HAIP 1 antibody; HAIP1 antibody; HIAP 1 antibody; HIAP-1 antibody; HIAP1 antibody; IAP homolog C antibody; IAP-1 antibody; Inhibitor of apoptosis protein 1 antibody; MALT 2 antibody; MALT2 antibody; Mammalian IAP homolog C antibody; MIHC antibody; RING finger protein 49 antibody; RNF49 antibody; TNFR2 TRAF signaling complex protein 1 antibody; TNFR2 TRAF signalling complex protein antibody; TNFR2-TRAF-signaling complex protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13489
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 3 protein (76-245AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1 and BCL10. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC3
Research Areas : Cancer; Cell biology; Metabolism