CAMK1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : Calcium / calmod µLin dependent protein kinase 1 antibody; Calcium / calmod µLin dependent protein kinase I antibody; Calcium / calmod µLin dependent protein kinase type 1 antibody; Calcium/calmod µLin dependent protein kinase 1 antibody; Calcium/calmod µLin dependent protein kinase I antibody; Calcium/calmod µLin dependent protein kinase type 1 antibody; Calcium/calmod µLin-dependent protein kinase type 1 antibody; CaM K1 antibody; CaM KI antibody; CaM kinase 1 alpha antibody; CAM kinase 1 antibody; CaM kinase I alpha antibody; CaM kinase I antibody; CaM-KI antibody; CaMK 1 antibody; CAMK I antibody; CaMK1 alpha antibody; CAMK1 antibody; CAMK1 PEN antibody; CaMKI alpha antibody; CaMKI-alpha antibody; KCC1A_HUMAN antibody; MGC120317 antibody; MGC120318 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14012
Immunogen : Recombinant Human Calcium/calmod µLin-dependent protein kinase type 1 protein (166-265AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Calcium/calmod µLin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, reg µLates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Reg µLates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for f µLl long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on \'Ser-694\', which res µLts in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on \'Ser-91\', \'Ser-92\', \'Ser-93\' and \'Ser-294\'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of \'Ser-259\' and \'Ser-498\' in the reg µLation of muscle cell differentiation. Reg µLates NUMB-mediated endocytosis by phosphorylation of NUMB on \'Ser-276\' and \'Ser-295\'. Involved in the reg µLation of basal and estrogen-stim µLated migration of med µLloblastoma cells thro µgh ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated reg µLation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1 ATF1 CFTR, MYL9 and SYN1/synapsin I.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CAMK1
Research Areas : Neuroscience; Cardiovasc µLar; Signal transduction