C4B Antibody

Volume : 50 µg
Clone Number :
Aliases : Basic complement C4 antibody; C2B5 antibody; C3 and PZP-like alpha-2-macroglob µLin domain-containing protein 3 antibody; C4b antibody; C4B1 antibody; C4B2 antibody; C4B3 antibody; CO4B_HUMAN antibody; Complement C4 gamma chain antibody; Complement component 4B antibody; CPAMD3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P0C0L5
Immunogen : Recombinant Human Complement C4-B protein (1454-1744AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, IHC; Recommended dilution : IHC : 1 : 20-1 : 200
Background : Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglob µLins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC thro µgh CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Ref.16 Ref.17 Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vasc µLar permeability and causes histamine release from mast cells and basophilic leukocytes.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Non-conj µgated
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : C4B
Research Areas : Immunology