ITGB3 (Ab 773) Antibody

Volume : 100 µL
Clone Number :
Aliases : BDPLT16 antibody; BDPLT2 antibody; CD 61 antibody; CD61 antibody; CD61 antigen antibody; GP3A antibody; GPIIIa antibody; GT antibody; HPA 1 antibody; HPA 4 antibody; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody; Integrin beta chain beta 3 antibody; Integrin beta-3 antibody; ITB3_HUMAN antibody; ITG B3 antibody; ITGB 3 antibody; ITGB3 antibody; NAIT antibody; platelet fibrinogen receptor antibody; Platelet fibrinogen receptor beta subunit antibody; Platelet fibrinogen receptor, beta subunit antibody; Platelet glycoprotein IIIa antibody; Platelet glycoprotein IIIa precursor antibody; Platelet membrane glycoprotein IIIa antibody; PTP antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P05106
Immunogen : Peptide sequence around aa. 771~775 (P-L-Y-K-E) derived from Human Integrin b3.
Raised in : Rabbit
Species Reactivity : Human, Mouse
Tested Applications : ELISA, WB, IHC; WB : 1 : 500-1 : 1000, IHC : 1 : 50-1 : 200
Background : Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomod µLin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction thro µgh binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically pl µgs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracell µLar viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Chandhoke SK, et al.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conj µgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conj µgate : Non-conj µgated
Buffer : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ITGB3
Research Areas : Cardiovasc µLar;Immunology;Signal transduction