IKBKB Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : I kappa B kinase 2 antibody; I kappa B kinase beta antibody; I-kappa-B kinase 2 antibody; I-kappa-B-kinase beta antibody; IkBKB antibody; IKK beta antibody; IKK-B antibody; IKK-beta antibody; IKK2 antibody; IKKB antibody; IKKB_HUMAN antibody; IMD15 antibody; Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta antibody; Inhibitor of nuclear factor kappa-B kinase subunit beta antibody; NFKBIKB antibody; Nuclear factor NF-kappa-B inhibitor kinase beta antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O14920
Immunogen : Recombinant Human Inhibitor of nuclear factor kappa-B kinase subunit beta protein (395-588AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by m µLtiple stim µLi such as inflammatory cytokines, bacterial or viral products, DNA damages or other cell µLar stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1 as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative reg µLation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IKBKB
Research Areas : Cancer; Cardiovasc µLar; Cell biology; Immunology; Signal transduction