FOXO1 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : FKH 1 antibody; FKH1 antibody; FKHR antibody; Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody; Forkhead box O1 antibody; Forkhead box protein O1 antibody; Forkhead box protein O1A antibody; Forkhead in rhabdomyosarcoma antibody; Forkhead; Drosophila; homolog of; in rhabdomyosarcoma antibody; FoxO transcription factor antibody; foxo1 antibody; FOXO1_HUMAN antibody; FOXO1A antibody; OTTHUMP00000018301 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q12778
Immunogen : Recombinant Human Forkhead box protein O1 protein (1-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Transcription factor that is the main target of ins µLin signaling and reg µLates metabolic homeostasis in response to oxidative stress. Binds to the ins µLin response element (IRE) with consensus sequence 5\'-TT[G/A]TTTTG-3\' and the related Daf-16 family binding element (DBE) with consensus sequence 5\'-TT[G/A]TTTAC-3\'. Activity suppressed by ins µLin. Main reg µLator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in reg µLating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and ins µLin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1 G6PC and PCK1. Important reg µLator of cell death acting downstream of CDK1 PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates ins µLin action on adipose tissue. Reg µLates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte Volume and adipose tissue-specific gene expression in response to excessive calorie intake. Reg µLates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FOXO1
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction