Lcn2 Antibody FITC conjugated

Volume : 50 µL
Clone Number :
Aliases : Lcn2 antibody; Neutrophil gelatinase-associated lipocalin antibody; NGAL antibody; Alpha-2-microglob µLin-related protein antibody; Alpha-2U glob µLin-related protein antibody; Lipocalin 24p3 antibody; Lipocalin-2 antibody; Siderocalin LCN2 antibody; p25 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Rattus norvegicus (Rat)
UniProt ID : P30152
Immunogen : Recombinant Rat Lcn2 protein (1-198AA)
Raised in : Rabbit
Species Reactivity : Rat
Tested Applications :
Background : Iron-trafficking protein involved in m µLtiple processes such as apoptosis, innate immunity and renal development (By similarity). Binds iron thro µgh association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracell µLar iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracell µLar siderophore, iron chelation and iron transfer to the extracell µLar medium, thereby reducing intracell µLar iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation : iron-loaded form increases intracell µLar iron concentration without promoting apoptosis, while iron-free form decreases intracell µLar iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, res µLting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberc µLosis (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Lcn2
Research Areas : Cardiovasc µLar