JAK3 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : EC 2.7.10.2 antibody; JAK 3 antibody; JAK L antibody; JAK-3 antibody; Jak3 antibody; JAK3 HUMAN antibody; JAK3_HUMAN antibody; JAKL antibody; Janus kinase 3 (a protein tyrosine kinase; leukocyte) antibody; Janus kinase 3 antibody; Janus Kinase3 antibody; L JAK antibody; L-JAK antibody; Leukocyte janus kinase antibody; LJAK antibody; Protein tyrosine kinase leukocyte antibody; Tyrosine protein kinase JAK3 antibody; Tyrosine-protein kinase JAK3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P52333
Immunogen : Recombinant Human Tyrosine-protein kinase JAK3 protein (351-614AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molec µLes bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : JAK3
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Signal transduction