FZD7 Antibody Biotin conjugated

Volume : 50 µL
Clone Number :
Aliases : Frizzled 7; seven transmembrane spanning receptor antibody; frizzled class receptor 7 antibody; Frizzled drosophila homolog of 7 antibody; Frizzled family receptor 7 antibody; Frizzled homolog 7 antibody; Frizzled-7 antibody; Frizzled7 antibody; Fz 7 antibody; Fz-7 antibody; Fz7 antibody; FZD 7 antibody; FZD7 antibody; FZD7_HUMAN antibody; FzE 3 antibody; FzE3 antibody; hFz 7 antibody; hFz7 antibody; Homolog of Drosophila Frizzled 7 antibody; OTTHUMP00000163742 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O75084
Immunogen : Recombinant Human Frizzled-7 protein (161-239AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accum µLation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercell µLar transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FZD7
Research Areas : Cancer; Signal transduction; Stem cells