FYN Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : C syn protooncogene antibody; Fyn antibody; FYN oncogene related to SRC FGR YES antibody; FYN_HUMAN antibody; OKT3 induced calcium influx reg µLator antibody; P59 FYN antibody; p59-Fyn antibody; Protein tyrosine kinase fyn antibody; Proto oncogene tyrosine protein kinase fyn antibody; Proto-oncogene c-Fyn antibody; Proto-oncogene Syn antibody; Protooncogene Syn antibody; SLK antibody; Src like kinase antibody; Src yes related novel gene antibody; Src-like kinase antibody; Src/yes related novel antibody; SYN antibody; Tyrosine kinase p59fyn T antibody; Tyrosine kinase p59fyn(T) antibody; Tyrosine-protein kinase Fyn antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P06241
Immunogen : Recombinant Human Tyrosine-protein kinase Fyn protein (154-270AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Non-receptor tyrosine-protein kinase that plays a role in many biological processes including reg µLation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1 allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the reg µLation of cell adhesion and motility thro µgh phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Reg µLates cytoskeletal remodeling by phosphorylating several proteins including the actin reg µLator WAS and the microtub µLe-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that reg µLate the integrity of the glomer µLar slit diaphragm (an essential part of the glomer µLar filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1 KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a m µLtifunctional adapter protein within the central nervous system, ARHGAP32, a reg µLator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stim µLation. Also participates in negative feedback reg µLation of TCR signaling thro µgh phosphorylation of PAG1 thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FYN
Research Areas : Neuroscience; Cancer; Signal transduction