CASP4 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : Apoptotic cysteine protease Mih1/TX antibody; CASP-4 antibody; CASP4 antibody; CASP4_HUMAN antibody; Caspase 4 apoptosis related cysteine peptidase antibody; Caspase-4 subunit 2 antibody; Caspase4 antibody; ICE(rel)-II antibody; ICE(rel)II antibody; ICEREL II antibody; ICH2 antibody; Mih1/TX antibody; Protease ICH-2 antibody; Protease TX antibody; TX antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P49662
Immunogen : Recombinant Human Caspase-4 protein (82-226AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Inflammatory caspase (PubMed : 7797510, PubMed : 23516580, PubMed : 25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed : 22246630, PubMed : 26174085, PubMed : 26173988, PubMed : 26508369, PubMed : 25964352). Independently of NLRP3 inflammasome and CASP1 promotes pyroptosis, thro µgh GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed : 24879791 PubMed : 25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed : 25121752). In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which µLtimately res µLts in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed : 26508369). Involved in cell death induced by endoplasmic retic µLum stress and by treatment with cytotoxic APP peptides found Alzheimer\'s patient brains (PubMed : 15123740, PubMed : 22246630, PubMed : 23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed : 25119034). Does not directly process IL1B (PubMed : 7743998, PubMed : 7797592, PubMed : 7797510).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CASP4
Research Areas : Cancer; Cell biology; Metabolism