AURKA Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : AIK antibody; ARK-1 antibody; ARK1 antibody; AURA antibody; Aurka antibody; Aurora 2 antibody; Aurora A antibody; Aurora kinase A antibody; Aurora-related kinase 1 antibody; Aurora/IPL1 like kinase antibody; AURORA/IPL1-like kinase antibody; Aurora/IPL1-related kinase 1 antibody; AURORA2 antibody; Breast tumor-amplified kinase antibody; BTAK antibody; hARK1 antibody; IAK antibody; IPL1 related kinase antibody; MGC34538 antibody; OTTHUMP00000031340 antibody; OTTHUMP00000031341 antibody; OTTHUMP00000031342 antibody; OTTHUMP00000031343 antibody; OTTHUMP00000031344 antibody; OTTHUMP00000031345 antibody; OTTHUMP00000166071 antibody; OTTHUMP00000166072 antibody; PPP1R47 antibody; Protein phosphatase 1 reg µLatory subunit 47 antibody; Serine/threonine kinase 15 antibody; Serine/threonine kinase 6 antibody; Serine/threonine protein kinase 15 antibody; Serine/threonine-protein kinase 15 antibody; Serine/threonine-protein kinase 6 antibody; Serine/threonine-protein kinase aurora-A antibody; STK15 antibody; STK6 antibody; STK6_HUMAN antibody; STK7 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O14965
Immunogen : Recombinant Human Aurora kinase A protein (1-131AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Mitotic serine/threonine kinases that contributes to the reg µLation of cell cycle progression. Associates with the centrosome and the spindle microtub µLes during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1 CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1 PARD3, PPP1R2, PLK1 RASSF1 TACC3, p53/TP53 and TPX2. Reg µLates KIF2A tub µLin depolymerase activity. Required for normal axon formation. Plays a role in microtub µLe remodeling during neurite extension. Important for microtub µLe formation and/or stabilization. Also acts as a key reg µLatory component of the p53/TP53 pathway, and partic µLarly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : AURKA
Research Areas : Cancer; Cell biology; Signal transduction