ABCB4 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : ABC 21 antibody; ABC B4 antibody; ABC21 antibody; ABCB 4 antibody; Abcb4 antibody; ABCB4 protein antibody; ATP binding cassette sub family B MDR/TAP member 4 antibody; ATP binding cassette sub family B member 4 antibody; ATP-binding cassette sub-family B member 4 antibody; GBD1 antibody; ICP3 antibody; MDR 3 antibody; MDR2 antibody; MDR2/3 antibody; MDR3 antibody; MDR3 P glycoprotein antibody; MDR3 P gp antibody; MDR3_HUMAN antibody; M µLtidr µg resistance protein 3 antibody; M µLtiple dr µg resistance 3 antibody; P glycoprotein 3 antibody; P-glycoprotein 3 antibody; PFIC 3 antibody; PFIC3 antibody; PGY 3 antibody; PGY3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P21439
Immunogen : Recombinant Human Phosphatidylcholine translocator ABCB4 protein (530-693AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Energy-dependent phospholipid efflux translocator that acts as a positive reg µLator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalic µLar membrane bilayer into the canalic µLi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canalic µLi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed : 7957936, PubMed : 8898203, PubMed : 9366571 PubMed : 17523162, PubMed : 23468132, PubMed : 24806754, PubMed : 24723470, PubMed : 24594635, PubMed : 21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molec µLes to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed : 23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalic µLar lumen in the presence of bile salts in an ATP-dependent manner (PubMed : 24045840). May promote biliary phospholipid secretion as canalic µLi-containing vesicles from the canalic µLar plasma membrane (PubMed : 9366571). In cooperation with ATP8B1 functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed : 21820390). Does not confer m µLtidr µg resistance (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ABCB4
Research Areas : Cancer; Metabolism; Signal transduction