EGLN1 / PHD2(366G/76/3) , 1mg / mL

This antibody recognises human prolyl hydroxylase 2 (PHD2) , a 46 kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex , consisting of an alpha and beta subunit , which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions , the alpha subunit of HIF-1 is rapidly degraded , however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit , thereby targeting this subunit for degradation. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.