Ferritin , Heavy Chain (FTH) (Microglia Marker)(FTH/2081) , 0.2mg / mL

Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains , ferritin heavy chain and ferritin light chain , which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage , the oxidationof FeI(II) , whereas ferritin light chains promote the nucleation of ferrihydrite , enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering , heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase , which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome , in which light chain ferritin is overexpressed; and oxidative stress , an important factor in the development of aging-related cataracts. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.