FOXA1 / HNF3A(FOXA1/1516) , CF594 conjugate , 0.1mg / mL

The transcription factor Forkhead-box A1 (FOXA1) , also known as hepatocyte nuclear factor 3-alpha , is a member of the FOX class of transcription factors. HNF-1 () , and HNF-6 compose , in part , a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney , small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs , such as lung , pancreas , bladder , prostate , and colon. Recently , FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity , especially in luminal subtype A breast cancers , which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.