Androgen Receptor(DHTR/882) , CF594 conjugate , 0.1mg / mL

This antibody recognizes a protein of 110 kDa , which is identified as androgen receptor (AR). It reacts with full length , and the newly described A form of the receptor. It does not cross react with estrogen , progesterone , or glucocorticoid receptors. AR functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand , the receptor dissociates from accessory proteins , translocates into the nucleus , dimerizes , and then stimulates transcription of androgen responsive genes. The expression of AR is reportedly inversely correlated with histologic grade; ie , well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer , AR has been proposed as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.