ALK CD246 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein res µLt in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cell µLar transformation. ALK translocations are found in a variety of tumors. Within the extracell µLar domain, human and mouse ALK share 88% amino acid sequence identity.
Immunogen : anaplastic lymphoma receptor tyrosine kinase
Aliases : ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
Observed MW : 140-220 kDa
Uniprot ID : Q9UM73
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC, WB
Recommended dilution : WB : 1 : 500-1 : 2000; IHC : 1 : 20-1 : 200
Gene ID : 238
Research Area : Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience