BATF Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Activating transcription factor B antibody; B ATF antibody; B-ATF antibody; B-cell-activating transcription factor antibody; Basic leucine zipper transcription factor like antibody; Basic leucine zipper transcriptional factor ATF like antibody; Basic leucine zipper transcriptional factor ATF-like antibody; Batf antibody; BATF_HUMAN antibody; BATF1 antibody; SF HT activated gene 2 protein antibody; SF-HT-activated gene 2 protein antibody; SFA 2 antibody; SFA-2 antibody; SFA2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q16520
Immunogen : Recombinant Human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system : specifically mediates the differentiation of T-helper 17 cells (Th17), follic µLar T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5\'-TGA[CG]TCA-3\'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5\'-TGAnTCA/GAAA-3\'), an immune-specific reg µLatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters : reg µLates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follic µLar T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Reg µLates effector CD8(+) T-cell differentiation by reg µLating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs) : up-reg µLated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BATF
Research Areas : Epigenetics and Nuclear Signaling