Fas (TNFRSF6) associated factor 1(CPTC-FAF1-2) , CF594 conjugate , 0.1mg / mL

In contrast to growth factors which promote cell proliferation , FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD , FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions , while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1 , for FAS-associated protein factor-1 , binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells , FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD , FADD and RIP , FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.