LIMS1 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background : The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling thro µgh its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also tho µght to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also s µggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Immunogen : LIM and senescent cell antigen-like domains 1
Aliases : PINCH, PINCH1
Observed MW : 40 kDa
Uniprot ID : P48059
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IF, IHC
Recommended dilution : WB : 1 : 500 - 1 : 2000; IHC : 1 : 50 - 1 : 200; IF : 1 : 50 - 1 : 100
Gene ID : 3987
Research Area : Signal Transduction